The increasing consumption of, and competition on, natural resources, in particular Water-Energy resources “WE-resources” is introducing new long-term and large-scale impacts on the sustainability of natural eco-systems and quality of life with major feedbacks socio-economic developments. Without credible environmental, social impact assessments and early-warning instruments, environmental compliance systems, rehabilitation measures and solid management policies can not be established whenever necessary. Impacts of large-scale manipulations of major river systems, as in this case, have rather slowly and unpredicted impacts on the environment and ecosystems. In addition, there are different regional consequence on re-location of population, water hydrology, farming and forests. Since the industrial revolution, and because of the ongoing globalization, there had been an accelerating consumption of energy and water resources. Currently, there are major threats, in some critical regions, resulting from transformations in energy policies, global warming, pollution and waste from industrial sectors as well as increasing consumption of natural resources.