Achieving sustainable socio-economic developments world-over depends on our understanding of the “Water-Energy nexus”, I call it WE-nexus. This is by no means the most important nexus for promoting golbal sustainability with considerable saving of WE-resources in terms of quality and quatity. How to use this nexus to get the magic-mix for best “quality and quantity” savings has no universal solution, it is dependent on how such resources can be managed through different levels of cooperation and shared responsibilty, e.g. on local, national, regional and global levels. Also, through adapting appropriate practices with consideration the geo-climatic conditions.