Our well-being on planet Earth depends on three main essential drivers, i.e. Water, Energy and Natural Resources (fossil minerals and renewables including biosphere and its eco-systems) ‘WENR’. To achieve sustainability and resilience in our societies and to promote prosperity requires using and sharing our common 'WENR' capital with consideration to the complex and multi-layered NEXUS, i.e. the interactions and processes within and between these three drivers 'WENR’. Currently, Earth is facing existential threats caused by us collectively. Scaling-Up and Scaling-Out 'Science, Technology and Innovation' of the WENR-systems and coupling them to the 'Socio-Economic-Environment' pillars of our societies as defined by the UN-SDGs are one of the very few means to mitigate existing and future threats and bring full vitality in the functioning and metabolism of all life forms and processes on Earth. Sustain-earth.com is an open access online platform that allows active contributions and feeback.