The Alliance for Global Water Adaptation founded in 2010 and involving regional and global development banks, government agencies and ministries, diverse non-governmental organizations (NGOs), and the private sector is focusing on managing water resources in a sustainable way. Though climate change is a major driver altering the global hydrological cycle still pollution and water are other man-made drivers influencing the global quality of natural waters. Water provides coherence to climate change adaptation and mitigation, integrating energy, water, food production and agriculture, and ecosystems and the environment. At the same time, the interaction with environmental changes in terms of increasing pollution and waste has strong threats on all life forms on earth with huge impacts on the quality of food and the health of ecosystems in general. Though AGWA is focused on how to help experts, decision makers, and institutions in the water community work more effectively, however there are still needs to consider sustainability in much wider perspective especially what regards the threats and impacts of pollution and waste, arising from production and consumption, on the hydrosphere, ecosphere and biodiversity.